学术著作

Lan, D., Zhao, G., Holzmann, N., Yuan, S.^*, Wang, J. & Wang, Y. Structure-guided rational design of a mono-and diacylglycerol lipase from Aspergillus oryzae: a single residue mutant increases the hydrolysis ability. Journal of Agricultural and Food Chemistry 69, 5344–5352 (2021).

Zhang, Y., Dijkman, P. M., Zou, R., Zandl-Lang, M., Sanchez, R. M., Eckhardt-Strelau, L., Köfeler, H., Vogel, H., Yuan, S. & Kudryashev, M. Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers. Nature communications 12, 1074 (2021).

Yao, D., Wang, Y., Zou, R., Bian, K., Yuan, S.^*, Zhang, B. & Wang, D. Wavelength-adjustable butterfly molecules in dynamic nanoassemblies for Extradomain-B fibronectin-modulating optical imaging and synchronous phototherapy of triple-negative breast cancer. Chemical Engineering Journal 420, 127658 (2021).

Liu, K., Zou, R., Cui, W., Li, M., Wang, X., Dong, J., Li, H., Li, H., Wang, P., Shao, X. & Yuan, S.^* Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2. ACS Pharmacol. Transl. Sci. (2020).

Dong, Q., Yuan, S., Wu, L., Su, L., Zhao, Q., Wu, J., Huang, W. & Zhou, J. Structure-guided engineering of a Thermobifida fusca cutinase for enhanced hydrolysis on natural polyester substrate. Bioresources and Bioprocessing 7, 37 (2020).

Liu, K., Wu, L., Yuan, S., Wu, M., Xu, Y., Sun, Q., Li, S., Zhao, S., Hua, T. & Liu, Z.-J. Structural basis of CXC chemokine receptor 2 activation and signalling. Nature 585, 135–140 (2020).

Cui, W., Aouidate, A., Wang, S., Yu, Q., Li, Y. & Yuan, S.^* Discovering anti-cancer drugs via computational methods. Frontiers in pharmacology 11, 733 (2020).

Hua, T., Li, X., Wu, L., Iliopoulos-Tsoutsouvas, C., Wang, Y., Wu, M., Shen, L., Johnston, C. A., Nikas, S. P., Song, F. & Yuan, S. Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures. Cell (2020).

Chan, S., Wu, Y., Tan, L., Vogel, H., Cheng, J., Wu, D. & Yuan, S.^* Enhancing the Signaling of GPCRs via Orthosteric Ions. ACS Central Science (2020).

Chen, X., Xu, Y., Qu, L., Wu, L., Han, G. W., Guo, Y., Wu, Y., Zhou, Q., Sun, Q., Chu, C. & Yuan, S. Molecular mechanism for ligand recognition and subtype selectivity of α2C adrenergic receptor. Cell reports 29, 2936–2943. e4 (2019).

Chan, H. C. S., Shan, H., Dahoun, T., Vogel, H. & Yuan, S.^* Advancing drug discovery via artificial intelligence. Trends in pharmacological sciences 40, 592–604 (2019).

Zheng, L., Falschlunger, C., Huang, K., Mairhofer, E., Yuan, S., Wang, J., Patel, D. J., Micura, R. & Ren, A. Hatchet ribozyme structure and implications for cleavage mechanism. Proceedings of the National Academy of Sciences 116, 10783–10791 (2019).

Yuan, S.^*, Dahoun, T., Brugarolas, M., Pick, H., Filipek, S. & Vogel, H. Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds. Communications biology 2, 141 (2019).

Liu, L., Chan, S., Mo, T., Ding, W., Yu, S., Zhang, Q. & Yuan, S.^* Movements of the substrate-binding clamp of cypemycin decarboxylase CypD. Journal of Chemical Information and Modeling 59, 2924–2929 (2019).

Chan, H. C. S., Li, Y., Dahoun, T., Vogel, H. & Yuan, S.^* New binding sites, new opportunities for GPCR drug discovery. Trends in biochemical sciences 44, 312–330 (2019).

Puławski, W., Yuan, S., Sztyler, A. & Orzeł, U. Modeling of Membrane Proteins. Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes: From Bioinformatics to Molecular Quantum Mechanics, 371 (2018).

Chan, H. C. S., Pan, L., Li, Y. & Yuan, S.^* Rationalization of stereoselectivity in enzyme reactions. Wiley Interdisciplinary Reviews: Computational Molecular Science, e1403 (2018).

Ernst, I., Haase, M., Ernst, S., Yuan, S., Kuhn, A. & Leptihn, S. Large conformational changes of a highly dynamic pre-protein binding domain in SecA. Communications biology 1, 130 (2018).

Chan, H. C. S., Wang, J., Palczewski, K., Filipek, S., Vogel, H., Liu, Z.-J. & Yuan, S.^* Exploring a new ligand binding site of G protein-coupled receptors. Chemical science 9, 6480–6489 (2018).

Yan, Y., Qikun, L., Zang, X., Yuan, S., Undramaa, B.-E., Calvin, N., Gan, J., Zhou, J., Jacobsen, S. E. & Tang, Y. Resistance-Gene Directed Discovery of a Natural Product Herbicide with a New Mode of Action. Nature (2018).